Concanavalin-A stimulates human chorionic gonadotropin (hCG) and hCG-alpha secretion by human choriocarcinoma cells |
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| Authors: | R Benveniste K V Speeg A Long D Rabinowitz |
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| Institution: | 1. Department of Medicine and Biochemistry Vanderbilt University School of Medicine Nashville, Tennessee 37232 USA;2. the V.A. Hospital Nashville, Tennessee 37232 USA |
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| Abstract: | The plant lectin Concanavalin-A stimulates the secretion of human chorionic gonadotropin and free alpha subunit by cultured human choriocarcinoma cells in a dose dependent and time dependent manner. This stimulation is prevented by alpha-methyl-D-mannopyranoside, a Concanavalin-A specific hapten sugar. This is the first report of a lectin stimulating the secretion of a glycoprotein hormone. Since the stimulation likely occurs subsequent to interactions at the membrane level, Concanavalin-A may represent a probe for studying membrane-related events involved in the control of human chorionic gonadotropin secretion. |
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