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Probable loss of tolerance and simulation of autoimmunization in induced chimeras in doves
Authors:Dee A. McGary  M. Nickells  G. Justines  M. R. Irwin
Affiliation:1. Laboratory of Genetics, University of Wisconsin, Madison, Wisconsin
2. Middle America Research Unit, Box 2011, Balboa Heights, Canal Zone
Abstract:Chimeras were induced in doves (Streptopelia) by making parabionts of embryonating eggs that carried genes for erythrocyte antigens, which were readily identified. The parabiotic pairs were chosen so that new antigenic specificities would appear if somatic cell mating took place. However, no evidence of somatic cell mating was noted. Erythrocytic chimerism was no longer. detectable in some birds after varying periods of time. In a few others tolerance was presumably lost, since their plasma contained antibodies against cellular antigens that either were present, or had been present, in the bird's circulation.
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