Correlation of the effects of citric acid cycle metabolites on succinate oxidation by rat liver mitochondria and submitochondrial particles |
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Authors: | M. Hillar V. Lott B. Lennox |
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Affiliation: | 1. Department of Biology, Texas Southern University, 77004, Houston, Texas
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Abstract: | - Succinate dehydrogenase is inhibited by citrate and β-hydroxybutyrate in a complex manner, both in mitochondria and submitochondrial particles. Kinetics of inhibition in the particles points to a competitive component in the mechanism involved.
- Pyruvate, α-ketoglutarate, malate, and glutamate stimulate oxidation of succinate by mitochondria.
- Stimulation by α-ketoglutarate and glutamate is not influenced by the presence of rotenone.
- Stimulation by pyruvate is higher in the absence of rotenone and increases significantly in the presence of K+ and valinomycin. Pyruvate supplies in mitochondria reducing equivalents for malate dehydrogenase operating in the reverse direction-reduction of oxaloacetate to malate.
- Stimulation by malate is higher in the presence of rotenone.
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