巨细胞病毒感染对新生豚鼠胸腺的影响

新生豚鼠皮下接种豚鼠巨细胞病毒(GPCMV)后,导致动物胸腺急性感染。感染豚鼠胸腺在接种后第五天开始出现病毒,第十天达高峰。此外,感染动物胸腺的发育受到抑制,细胞总数和T淋巴细胞数随朐腺中病毒滴度的增高而进行性下降,至接种GPCMV后第十天最显著。由于病毒对T细胞的作用,细胞表面红细胞受体的丧失导致胸腺Null细胞百分比高于对照动物。

EFFECT OF CYTOMEGALOVIRUS INFECTION ON THE THYMUS OF NEONATAL GUINEA PIGS

Sc. inoculation of neonatal guinea pigs with guinea pig cytomegalovirus (GPCMV)resulted in acute infection of thymus. Infectious virus could be recovered from the thymus of infected animals at 5 days postinfection and the highest titers ef infections virus appeared at 10 days postinfection. The weights, total numbers of cells and T-rosette ferming cells were significantly lower in the thymus of GPCMV-infected animals tested on days 7 to 16, specially on day 10 postinfection as compared to control animals Although no alterations ef the numbers of B lymphocytes and phagocytes were observed in the thymus of infected animals, the percentages of thymic Null cells were higher in GPCMV-infected animals than in controls since GPCMV-infected T lymphocytes and might result in the loss of rabbit red blood cells receptors on the surface ef T cells.