Acetyl glyceryl ether phosphorylcholine (platelet-activating factor) mediates heightened metabolic activity in macrophages: Studies on PGE, TXB2 and O2 production, spreading, and the influence of calmodulin-inhibitor W-7 |
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Authors: | Hans-Peter Hartung |
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Abstract: | The phospholipid mediator AGEPC (acetyl glyceryl ether phosphorylcholine) was examined for its effects on guinea pig peritoneal macrophages. At a concentration of 10?9 -10?6 M, AGEPC evoked release of prostaglandin E (PGE) and thromboxane B2 (TXB2) from albumin-elicited macrophages. It also triggerd generation of O?2 by Corynebacterium parvum-induced cells. Moreover, it caused augmented spreading of macrophages. The calmodulin antagonis W-7 attenuated AGEPC-mediated O?2 production and cell spreading whereas prostanoid synthesis was enhanced. These novel actions of AGEPC on the major cellular component of the inflammatory process attest to its role as a potent mediator of immunoinflammatory responses. |
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Keywords: | Platelet-activating factor Macrophage Prostanoid O?2 Spreading Calmodulin antagonis W-7 |
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