Synthesis of dl-4,5,6-trinor-3,7-inter-m-phenylene-3-oxaprostaglandins including one which inhibits platelet aggregation |
| |
Authors: | Norman A. Nelson R.W. Jackson A.T. Au D.J. Wynalda E.E. Nishizawa |
| |
Affiliation: | aResearch Laboratories, The Upjohn Company, Kalamazoo, Michigan 49001, USA |
| |
Abstract: | The synthesis of dl-4,5,6-trinor-3,7-inter-m-phenylene-3-oxaprostaglandins of the E1 and F1 series** from 6-endo-(1-heptenyl)-bicyclo[3:1:0]hexan-3-one (III), is described. Preliminary biological screening data for gerbil colon smooth muscle stimulation, rat blood pressure and substrate specificity toward 15-hydroxyprostaglandin dehydrogenase is presented. Platelet function studies, both in vitro and in vivo of dl-4,5,6-trinor-3,7-inter-m-phenylene-3-oxa-PGE1, methyl ester (VIII) are presented. |
| |
Keywords: | |
本文献已被 ScienceDirect 等数据库收录! |
|