| Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection? |
| |
| 引用本文： | Bertoletti A,Maini MK. Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?[J]. Current opinion in microbiology, 2000, 3(4): 387-392. DOI: 10.1016/S1369-5274(00)00109-0 |
| |
| 作者姓名： | Bertoletti A Maini MK |
| |
| 摘 要： |
|
Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection? |
| |
| Bertoletti A,Maini M K. Protection or damage: a dual role for the virus-specific cytotoxic T lymphocyte response in hepatitis B and C infection?[J]. Current opinion in microbiology, 2000, 3(4): 387-392. DOI: 10.1016/S1369-5274(00)00109-0 |
| |
| Authors: | Bertoletti A Maini M K |
| |
| Affiliation: | Institute of Hepatology, University College London Medical School, UK. a.bertoletti@ucl.ac.uk |
| |
| Abstract: | During infection with hepatitis B or C viruses, cytotoxic T lymphocytes (CTLs) have been implicated as both the mediators of protection and the principal effectors of liver pathology. Recent studies have allowed an investigation of the relationship between virus-specific CTL responses, liver damage and viral replication. In the presence of an efficient virus-specific CTL response, a scenario is emerging where inhibition of viral replication can be independent of liver pathology. We discuss the possibility that an inadequate CTL response--unable to control viral replication--may contribute to liver pathology not only directly but also via the recruitment of non-virus-specific T cells. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
