Structural features of piperazinyl-linked ciprofloxacin dimers required for activity against drug-resistant strains of Staphylococcus aureus |
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| Authors: | Kerns Robert J Rybak Michael J Kaatz Glenn W Vaka Flamur Cha Raymond Grucz Richard G Diwadkar Veena U |
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| Institution: | Division of Medicinal and Natural Products Chemistry, The University of Iowa, 52242, Iowa City, IA, USA. robert-kerns@uiowa.edu |
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| Abstract: | We previously demonstrated that piperazinyl-linked fluoroquinolone dimers possess potent antibacterial activity against drug-resistant strains of Staphylococcus aureus. In this study, we report the preparation and evaluation of a series of incomplete dimers toward ascertaining structural features of piperazinyl-linked ciprofloxacin dimers that render these agents refractory to fluoroquinolone-resistance mechanisms in Staphylococcus aureus. |
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