Influence of metabolic network structure and function on enzyme evolution |
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| Authors: | Dennis Vitkup Peter Kharchenko Andreas Wagner |
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| Affiliation: | (1) Department of Biomedical Informatics, Center for Computational Biology and Bioinformatics, Columbia University, Russ Berrie Pavilion, St Nicholas Avenue, New York, NY 10032, USA;(2) Department of Genetics, Harvard Medical School, New Research Building, Ave Louis Pasteur, Boston, MA 02115, USA;(3) Department of Biology, Castetter Hall, University of New Mexico, Albuquerque, NM 87131, USA |
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| Abstract: | Background Most studies of molecular evolution are focused on individual genes and proteins. However, understanding the design principles and evolutionary properties of molecular networks requires a system-wide perspective. In the present work we connect molecular evolution on the gene level with system properties of a cellular metabolic network. In contrast to protein interaction networks, where several previous studies investigated the molecular evolution of proteins, metabolic networks have a relatively well-defined global function. The ability to consider fluxes in a metabolic network allows us to relate the functional role of each enzyme in a network to its rate of evolution. |
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