Effects of helodermin on fetal rat bone metabolism in vitro |
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Authors: | J Pfeilschifter A Naumann M Oechsner R Ziegler |
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Institution: | Department of Endocrinology and Metabolism, University of Heidelberg, West Germany. |
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Abstract: | Helodermin belongs to the VIP family of polypeptides. Recent in vivo data suggest that helodermin-like peptides might be involved in the regulation of calcium metabolism. We show that helodermin specifically binds to a secretin-type receptor in osteoblast-like cells from fetal rat calvaria and increases the basal and PTH-stimulated cAMP concentration of these cells. In organ cultures of fetal rat calvaria, helodermin strongly inhibits bone matrix apposition and augments PTH-induced bone resorption. Helodermin-like peptides may thus be capable of enhancing the direct effects of PTH on bone metabolism. |
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