Pattern formation during vulval development in C. elegans |
| |
| Authors: | P W Sternberg H R Horvitz |
| |
| Affiliation: | 9. Emergency Department, Daqing Longnan Hospital, Daqing, Heilongjiang, China;99. Coronary Care Unit, Daqing Longnan Hospital, Daqing, Heilongjiang, China;1. Department of Biochemistry, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Pondicherry, India;2. Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Karaikal, India;3. Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Pondicherry, India;4. Department of General Medicine, Mahatma Gandhi Medical College and Research Institute, Sri Balaji Vidyapeeth University, Pondicherry, India;1. MRC Centre for Developmental Neurobiology, King’s College London, London SE1 1UL, UK;2. Molecular Neurophysiology Laboratory, Signature Program in Neuroscience and Behavioral Disorders, Duke NUS Graduate Medical School, 8 College Road, 169857 Singapore, Singapore;3. Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, 117597 Singapore, Singapore;4. Department of Bioinformatics and Computational Biology, Genentech, South San Francisco, CA 94080, USA;5. School of Biological Sciences, Nanyang Technological University, 637551 Singapore, Singapore;1. Immunology and Oncology Department, National Center for Biotechnology, CSIC, 28049 Madrid, Spain;2. Department of Cardiovascular Development and Repair, Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III, 28029 Madrid, Spain;3. Cardiovascular Area, CIMUS, University of Santiago de Compostela-Instituto de Investigación Sanitaria, 15706 Santiago de Compostela, Spain;4. Institute of Pharmacology, Heart Research Center Göttingen, University Medical Center, Georg-August University Göttingen and DZHK (German Center for Cardiovascular Research), 37075 Göttingen, Germany;5. Instituto de Investigación Sanitaria INCLIVA, 46010 Valencia, Spain;6. Unidad de Cardioregeneración, Hospital La Fe, 46009 Valencia, Spain;7. Servicio de Cardiología, Hospital Clínico San Carlos, 28040 Madrid, Spain;8. Departamento de Patología, Facultad de Medicina, Universidad de Valencia, 46010 Valencia, Spain;1. Institute of Neuroanatomy, University Medical Center, Georg-August-University, 37075 Goettingen, Germany;2. German Center for Neurodegenerative Diseases, 37075 Goettingen, Germany;3. Max-Planck-Institute for Biophysical Chemistry, 37077 Goettingen, Germany;4. Department of Biological Sciences, Institute of Molecular Biology and Genetics, Seoul National University, Seoul 08826, Korea;5. DFG, Center for Molecular Physiology of the Brain (CMPB), 37075 Goettingen, Germany;6. Department of Anatomy and Cell Biology, Medical University-Varna, BG-9002 Varna, Bulgaria |
| |
| Abstract: | Previous studies have shown that the development of the vulva of the C. elegans hermaphrodite involves six multipotential hypodermal cells as well as the gonadal anchor cell, which induces vulval formation. Our further examination of the interactions among these seven cells has led to the following model. Each hypodermal precursor cell becomes determined to adopt one of its three potential fates; each of these fates is to generate a particular cell lineage. In the absence of cellular interactions each precursor cell will generate the nonvulval cell lineage; an inductive signal from the anchor cell is required for a precursor cell to generate either of the two types of vulval cell lineages. The inductive signal is spatially graded, and the potency of the signal specifies which lineage is expressed by each of the tripotential precursor cells. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect PubMed 等数据库收录！ |
|
