A new inhibitor of adenine nucleotide translocase in mitochondria: agaric acid. |
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| Authors: | E Chávez M Klapp |
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| Institution: | Departamento de Biología Experimental, Instituto de Biología Universidad Nacional Autónoma de México, Ciudad Universitaria México, 20, D. F., Mexico |
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| Abstract: | The effect of agaric acid (α cetyl citric acid) on the transport of ADP and ATP has been examined in rat liver mitochondria. Respiration stimulated by ADP is progresively inhibited by agaric acid; maximal inhibition is attained at 40 μM agaric acid. ATPase activity is inhibited 30% by 20 μM agaric acid. The exchange of adenine nucleotides is competitively inhibited by agaric acid. |
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