Galectin-3 as a multifunctional protein |
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Authors: | Krześlak Anna Lipińska Anna |
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Institution: | University of ?ód?, Department of Cytobiochemistry, Banacha 12/16, 90-237 ?ód?, Poland. |
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Abstract: | Galectin-3 is a 31 kDa member of a growing family of beta-galactoside-binding animal lectins. This protein is expressed in a variety of tissues and cell types and is mainly found in the cytoplasm, although, depending on cell type and proliferative state, a significant amount of this lectin can also be detected in the nucleus, on the cell surface or in the extracellular environment. Galectin-3 is secreted from cells by a novel and incompletely understood mechanism that is independent of the classical secretory pathway through the endoplasmic reticulum/Golgi network. Galectin-3 exhibits pleiotropic biological function, playing a key role in many physiological and pathological processes. |
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