Synthesis and in vitro photodynamic activity of mono-substituted amphiphilic zinc(II) phthalocyanines |
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Authors: | Lo Pui-Chi Zhao Baozhong Duan Wubiao Fong Wing-Ping Ko Wing-Hung Ng Dennis K P |
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Institution: | Department of Chemistry and Center of Novel Functional Molecules, The Chinese University of Hong Kong, Shatin, NT, Hong Kong, China. |
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Abstract: | A series of novel zinc(II) phthalocyanines mono-substituted with a 1,3-bis(dimethylamino)-2-propoxy group at the alpha- or beta-position, and the corresponding di-N-methylated derivatives, have been synthesized. All these compounds can generate singlet oxygen effectively and exhibit high in vitro photodynamic activities toward HT29 human colorectal carcinoma cells with IC(50) values down to 0.08microM. The dicationic derivatives have a higher affinity to the cell membrane compared with the non-ionic counterparts. |
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