Susceptibility of endothelial cells derived from different blood vessels to common viruses |
| |
Authors: | Harvey M. Friedman Jayneann Wolfe Nicholas A. Kefalides Edward J. Macarak |
| |
Affiliation: | (1) Joseph Stokes Jr. Research Institute of the Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania;(2) Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania;(3) Connective Tissue Research Institute, University of Pennsylvania, Philadelphia, Pennsylvania |
| |
Abstract: | Summary We examined whether endothelial cells derived from different blood vessels vary in their susceptibility to viral infection. Five common viral pathogens of humans (herpes simplex 1, measles, mumps, echo 9, and coxsackie B4 viruses) were evaluated for growth in endothelial cells derived from bovine fetal pulmonary artery thoracic aorta, and vena cava. All five viruses replicated in each type of endothelial cell. There were apparent differences in the quantities of measles and mumps viruses produced in pulmonary artery endothelium compared with thoracic aorta and vena cava when endothelial cells were obtained from different animals. However when pulmonary artery endothelial cells were compared with vena cava cells from the same animal, growth of each virus was similar in the two cell types. Four of the viruses replicated in the various endothelial cells without producing appreciable changes in cell morphology. These results indicate that endothelial cells from different blood vessels are equally susceptible to the human viruses evaluated, and that viral replication can occur without major alteration in cell morphology. Endothelial cells could serve as permissive cells permitting viruses to leave the circulation and initiate infection in adjacent tissues, including subendothelial smooth muscle cells. This work was supported by Public Health Service grants HL28220, HL 29492, and HL 24914 from the National Heart, Lung and Blood Institute, Bethesda, MD. |
| |
Keywords: | endothelial cells viruses herpes simplex virus |
本文献已被 SpringerLink 等数据库收录! |
|