Detecting early kidney damage in horses with colic by measuring matrix metalloproteinase -9 and -2, other enzymes,urinary glucose and total proteins |
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| Authors: | Bela M Arosalo Marja Raekallio Minna Rajamäki Elina Holopainen Tuulia Kastevaara Hanna Salonen Satu Sankari |
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| Affiliation: | (1) Department of Equine and Small Animal Medicine, Pharmacology and Toxicology, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, 00014, Finland |
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| Abstract: | Background The aim of the study was to investigate urine matrix metalloproteinase (MMP-2 and -9) activity, alkaline phosphatase/creatinine (U-AP/Cr) and gamma-glutamyl-transpeptidase/creatinine (U-GGT/Cr) ratios, glucose concentration, and urine protein/creatinine (U-Prot/Cr) ratio and to compare data with plasma MMP-2 and -9 activity, cystatin-C and creatinine concentrations in colic horses and healthy controls. Horses with surgical colic (n = 5) were compared to healthy stallions (n = 7) that came for castration. Blood and urine samples were collected. MMP gelatinolytic activity was measured by zymography. |
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