MMP-2及MMP-9与主动脉疾病相关性的研究进展

基质金属蛋白酶是一类可降解细胞外基质的蛋白酶,基质金属蛋白酶-2和-9为明胶酶,可降解细胞外基质中的胶原蛋白及弹性蛋白,其动态平衡对维持细胞外基质的稳定具有重要意义。主动脉的细胞外基质是主动脉中层重要的组成部分,细胞外基质成分的改变可导致主动脉中层结构的损伤,在主动脉疾病的发生、发展过程中起着重要作用。主动脉基质金属蛋白酶-2和-9的表达失衡可引起主动脉中层细胞外基质的降解,导致主动脉中层结构的损伤,从而促进主动脉疾病的发生。同时,主动脉疾病也可导致血浆中MMP-2、MMP-9浓度的升高。本文对近年来基质金属蛋白酶与主动脉疾病相关性的研究及进展作一综述,为心血管疾病发生机制的研究和治疗提供文献依据。

Research Progress of the Relationship of MMP-2 and MMP-9 with theAorta-related Disease

Matrix metalloproteinases can degrade extracellular matrix. Matrix metalloproteinase-2 and -9 are the gelatinases thatcan degree collagen and elastin. The balance of matrix metalloproteinase-2 and -9 plays the pivotal role in the stability of extracellularmatrix. Extracellular matrix is one of the important components in the aortic media. The changing of extracellular matrix can result in theinjury of aortic media, which can lead to aortic disease. The overexpression of matrix metalloproteinase-2 and -9 in can degreeextracellular matrix excessively, which is related to the aortic diseases. What''s more, the aortic diseases can also lead to the higer level ofMMP-2 and MMP-9. This paper reviewed the researches and progess of the relationship of the matrix metalloproteinase and the aorticdisease so as to provide a reference for the clinical treatment.