|
|||||
|
|
Evolution and structure of two ADP-ribosylation enterotoxins, Escherichia coli heat-labile toxin and cholera toxin |
|
| Authors: | T Yamamoto T Nakazawa T Miyata A Kaji T Yokota |
| Institution: | 1. Department of Bacteriology, School of Medicine, Juntendo University, 2-1-1 Hongo, Bunkyo-ku, Tokyo, Japan;2. Department of Biochemistry, Yamaguchi University, School of Medicine, Ube, Yamaguchi, Japan;3. Department of Biology, Kyushu University, Faculty of Science, Fukuoka, Japan;4. Department of Microbiology, School of Medicine, University of Pennsylvania, Philadelphia, PA, USA |
| Abstract: | Nucleotide sequence comparisons of the heat-labile enterotoxin (LTh) genes of E. coli pathogenic for humans with cholera toxin (CT) genes suggest that the two toxin genes have evolved from a common ancestry by a series of single base changes, while conserving the catalytic fragment A1 (ADP-ribose transferase). Based on the local hydrophilicity profiles of LTh and CT peptides, a transmembrane segment appears to be present in A1 in both toxins. |
| Keywords: | heat-labile enterotoxin Cholera toxin Sequence comparison ADP-ribosetransferase Transmembrane |
| 本文献已被 ScienceDirect 等数据库收录！ | |