A-to-I RNA editing modulates the pharmacology of neuronal ion channels and receptors |
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Authors: | A K Streit N Decher |
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Institution: | Institute for Physiology and Pathophysiology, Vegetative Physiology, Philipps University Marburg, Marburg, 35037, Germany. |
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Abstract: | The regulation of neuronal excitability is complex, as ion channels and neurotransmitter receptors are underlying a large
variety of modulating effects. Alterations in the expression patterns of receptors or channel subunits as well as differential
splicing contribute to the regulation of neuronal excitability. RNA editing is another and more recently explored mechanism
to increase protein diversity, as the genomic recoding leads to new gene products with novel functional and pharmacological
properties. In humans A-to-I RNA editing targets several neuronal receptors and channels, including GluR2/5/6 subunits, the
Kv1.1 channel, and the 5-HT2C receptor. Our review summarizes that RNA editing of these proteins does not only change protein function, but also the pharmacology
and presumably the drug therapy in human diseases. |
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