Applications of urinary proteomics in biomarker discovery |
| |
Authors: | Chen Shao Yan Wang YouHe Gao |
| |
Institution: | 1.National Key Laboratory of Medical Molecular Biology, Department of Physiology and Pathophysiology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences/School of Basic Medicine,Peking Union Medical College,Beijing,China |
| |
Abstract: | Urine is an important source of biomarkers. This article reviews current advances, major challenges, and future prospects
in the field of urinary proteomics. Because the practical clinical problem is to distinguish diseases with similar symptoms,
merely comparing samples from patients of a particular disease to those of healthy individuals is inadequate for finding biomarkers
with sufficient diagnostic power. In addition, the variation of expression levels of urinary proteins among healthy individuals
and individuals under different physiological conditions adds to the difficulty in identifying biomarkers. We propose that
establishing the natural variation in urinary protein expression among a healthy population can serve as a reference to help
identify protein abundance changes that are caused by disease, not by individual variations or physiological changes. We also
discuss that comparing protein expression levels between urine and plasma may reveal the physiological function of the kidney
and that may facilitate biomarker discovery. Finally, we propose that establishing a data-sharing platform for data collection
and integrating results from all urinary biomarker studies will help promote the development of urinary proteomics. |
| |
Keywords: | |
本文献已被 PubMed SpringerLink 等数据库收录! |
|