FACT: Functional annotation transfer between proteins with similar feature architectures |
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Authors: | " target="_blank">Tina Koestler " target="_blank">Arndt von Haeseler " target="_blank">Ingo Ebersberger |
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Institution: | (1) Max F. Perutz Laboratories, Center for Integrative Bioinformatics Vienna (CIBIV), Dr. Bohrgasse 9, A-1030 Vienna, Austria;(2) University of Vienna, Vienna, Austria;(3) Medical University of Vienna, Vienna, Austria;(4) University of Veterinary Medicine, Vienna, Austria |
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Abstract: | Background The increasing number of sequenced genomes provides the basis for exploring the genetic and functional diversity within the
tree of life. Only a tiny fraction of the encoded proteins undergoes a thorough experimental characterization. For the remainder,
bioinformatics annotation tools are the only means to infer their function. Exploiting significant sequence similarities to
already characterized proteins, commonly taken as evidence for homology, is the prevalent method to deduce functional equivalence.
Such methods fail when homologs are too diverged, or when they have assumed a different function. Finally, due to convergent
evolution, functional equivalence is not necessarily linked to common ancestry. Therefore complementary approaches are required
to identify functional equivalents. |
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Keywords: | |
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