Immunization with a dominant-negative recombinant Herpes Simplex Virus (HSV) type 1 protects against HSV-2 genital disease in guinea pigs |
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| Authors: | Richard Brans Feng Yao |
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| Institution: | (1) Department of Surgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA;(2) Department of Dermatology and Allergology, University Hospital of the RWTH Aachen, 52074 Aachen, Germany |
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| Abstract: | Background CJ9-gD is a novel dominant-negative recombinant herpes simplex virus type 1 (HSV-1) that is completely replication-defective,
cannot establish detectable latent infection in vivo, and expresses high levels of the major HSV-1 antigen glycoprotein D immediately following infection. In the present
study, CJ9-gD was evaluated as a vaccine against HSV-2 genital infection in guinea pigs. |
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