Ectodermal Wnt6 is an early negative regulator of limb chondrogenesis in the chicken embryo |
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| Authors: | Poongodi Geetha-Loganathan Suresh Nimmagadda Bodo Christ Ruijin Huang Martin Scaal |
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| Affiliation: | (1) Institute of Anatomy and Cell Biology, Department of Molecular Embryology, University of Freiburg, Albertstrasse 17, D-79104 Freiburg, Germany;(2) Department of Oral Health Sciences, Life Sciences Institute, Life Sciences Centre, University of British Columbia, 2350 Health Sciences Mall, Vancouver, V6T 1Z3, BC, Canada;(3) Department of Neuroanatomy, Insitute of Anatomy, Nussallee, D-53115, Bonn, Germany |
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| Abstract: | Background Pattern formation of the limb skeleton is regulated by a complex interplay of signaling centers located in the ectodermal sheath and mesenchymal core of the limb anlagen, which results, in the forelimb, in the coordinate array of humerus, radius, ulna, carpals, metacarpals and digits. Much less understood is why skeletal elements form only in the central mesenchyme of the limb, whereas muscle anlagen develop in the peripheral mesenchyme ensheathing the chondrogenic center. Classical studies have suggested a role of the limb ectoderm as a negative regulator of limb chondrogenesis. |
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