The Ah Locus: Biochemical Basis for Genetic Differences in Brain Tumor Formation in Mice |
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| Authors: | Roy C. Levitt Jacquelene M. Fysh Nancy M. Jensen Daniel W. Nebert |
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| Affiliation: | Developmental Pharmacology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20205 |
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| Abstract: | Allelic differences at the Ah locus are showen to exist in the mouse brain. This finding probably explains inbred mouse strain differences in polycyclic hydrocarbon tumorigenesis of the brain described more than 35 years ago and may be important in understanding the etiology of genetic differences in certain human intracranial neoplasms. |
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