Dose—response relationship for X-ray-induced reciprocal translocations in stem-cell spermatogonia of the rhesus monkey (Macaca mulatta) |
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Authors: | Paul P.W. van Buul |
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Affiliation: | 1. Department of Radiation Genetics and Chemical Mutagenesis, State University of Leiden, Sylvius Laboratories, Wassenaarseweg 72, Leiden, The Netherlands;2. J.A. Cohen Institute Interuniversity Institute for Radiopathology and Radiation Protection, Leiden, The Netherlands |
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Abstract: | The induction of reciprocal translocation in stem-cell spermatogonia of the rhesus monkey (Macaca mulatta) was studied after testicular X-irradiation of mature males (50, 100 and 200 rad) or whole-body irradiation of young males (200 and 300 rad). After the recovery of the germinal epithelium, cytogenetic analysis was carried out on spermatocytes descended from irradiation spermatogonia. Preparations of C-banded diakinesis-metaphase I were screened for translocation configurations. The frequencies of abberations obtained were 0% at 0 rad, 0.36% at 50% rad, 0.86% at 100 rad, 0.99% at 200 rad and 0.68% at 300 rad, suggesting a humped dose—response relationship. There was no evidence for the contribution of a quadratic component to the yield in the lower dose range. A comparison of these results with those obtained for other mammals by a number on investigators shows that the frequencies of translocations in the rhesus monkey are much lower than those published for most other mammalian species. |
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