首页 | 本学科首页   官方微博 | 高级检索  
   检索      


Substrates and inhibitors of hepatic amine oxidase inhibit dimethylnitrosamine-induced mutagenesis in Salmonella typhimurium
Authors:IR Rowland  BG Lake  JC Phillips  SD Gangolli
Institution:The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS Great Britain
Abstract:The mutagenic effect of dimethylnitrosamine in Salmonella typhimurium TA100, in the presence of a rat-liver homogenate derived from animals treated with Aroclor 1254, was inhibited by substrates and inhibitors of monoamine oxidase. Substrates of diamine oxidase did not inhibit dimethylnitrosamine mutagenesis and, furthermore, monoamine oxidase inhibitors had no effects on mutagenesis by benzoa]pyrene or aflatoxin B1. The results suggest that monoamine oxidase participates in the activation of dimethylnitrosamine to a mustagen.
Keywords:DMN  dimethylnitrosamine  MAO  monoamine oxidase
本文献已被 ScienceDirect 等数据库收录!
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号