Substrates and inhibitors of hepatic amine oxidase inhibit dimethylnitrosamine-induced mutagenesis in Salmonella typhimurium |
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Authors: | IR Rowland BG Lake JC Phillips SD Gangolli |
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Institution: | The British Industrial Biological Research Association, Woodmansterne Road, Carshalton, Surrey SM5 4DS Great Britain |
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Abstract: | The mutagenic effect of dimethylnitrosamine in Salmonella typhimurium TA100, in the presence of a rat-liver homogenate derived from animals treated with Aroclor 1254, was inhibited by substrates and inhibitors of monoamine oxidase. Substrates of diamine oxidase did not inhibit dimethylnitrosamine mutagenesis and, furthermore, monoamine oxidase inhibitors had no effects on mutagenesis by benzoa]pyrene or aflatoxin B1. The results suggest that monoamine oxidase participates in the activation of dimethylnitrosamine to a mustagen. |
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Keywords: | DMN dimethylnitrosamine MAO monoamine oxidase |
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