Natulan,a bacterial mutagen requiring complex mammalian metabolic activation |
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Authors: | A.K. Solt S. Neale |
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Affiliation: | Courtauld Institute of Biochemistry, The Middlesex Hospital Medical School, Mortimer Street, London W1P 7PN, Great Britain |
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Abstract: | Following administration of NatulanR and Escherichia coli to mice a dose-dependent increase in the frequency of induced bacterial mutations was observed. This mutation response was dependent on the route of Natulan administration and, following short exposures, was limited by the rate of metabolic activation of the compound. |
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