Chromosomal aberrations in peripheral lymphocytes of alcoholics |
| |
| Authors: | G. Obe D. Göbel H. Engeln J. Herha A.T. Natarajan |
| |
| Affiliation: | 1. Institut für Genetik, Freie Universität Berlin, Arnimallee 5-7, D-1000 Berlin 33 F.R.G.;2. Abteilung für Psychiatrie und Neurologie des Kindes- und Jugendalters der Psychiatrischen und Neurologischen Klinik und Poliknik, Freie Universität Berlin, Platanenallee 23, D-1000 Berlin 19 F.R.G.;3. Facharzt für Psychiatrie und Neurologie, Hafenstrasse 174, D-285 Bremerhaven-Lehe F.R.G.;4. Psychiatrische Klinik, Eschenallee 3, D-1000 Berlin 19 F.R.G.;5. Department of Radiation Genetics and Chemical Mutagenesis, University of Leiden, Sylvuis Laboratories, Wassenaarseweg 72, AL-2333 Leiden The Netherlands;6. J.A. Cohen Interuniversity Institute for Radiation Pathology and Radiation Protection, Leiden The Netherlands |
| |
| Abstract: | The frequencies of exchange-type aberrations found in peripheral lymphocytes of alcoholics were analysed in relation to age, sex, duration of alcohol dependency, treatment with antabuse and smoking habit. The statistical analyses were performed by the non-parametric Mann-Whitney U test and the Kruskal-Wallis 1-way analysis of vairance, both at a level of significance of P = 0.05. There was no dependency on age or sex. The chromatid exchange frequencies and the total of all exchanges were positively correlated with the duration of the dependency on alcohol and with smoking habit. Treatment with antabuse did not lead to an additional elevation of the frequency of exchange-type aberrations. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
