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Serial Expression of the Truncated Fragments of the Nucleocapsid Protein of CCHFV and Identification of the Epitope Region |
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| Authors: | Peng-fei WEI Yan-jun LUO Tian-xian LI Hua-lin WANG Zhi-hong HU Fu-chun ZHANG Yu-jiang ZHANG Fei DENG Su-rong SUN |
| Institution: | Peng-fei WEI 1,Yan-jun LUO 2,Tian-xian LI 2,Hua-lin WANG 2,Zhi-hong HU 2,Fu-chun ZHANG 1,Yu-jiang ZHANG 3,Fei DENG 2** , Su-rong SUN 1** (1.Xinjiang Key Laboratory of Biological Resources , Genetic Engineering,College of Life Science , Technology,Xinjiang University,Urumqi 830046,China,2.State Key Laboratory of Virology,Wuhan Institute of Virology,Chinese Academy of Sciences,Wuhan 430071,3.The Center for Disease Control , Prevention of Xinjiang Uygur Autonomous Region,Urumqi 830002,Chi... |
| Abstract: | The Crimean-congo hemorrhagic fever virus(CCHFV)is a geographically widespread fatal pathogen. Identification of the epitope regions of the virus is important for the diagnosis and epidemiological studies of CCHFV infections.In this study,expression vectors carrying series truncated fragments of the NP(nucleocapsid protein)gene from the S fragment of CCHFV strain YL04057 were constructed.The recombinant proteins were expressed in E.coli and purified for detection.The antigenic of the truncated fragments of ... |
| Keywords: | Crimean-congo hemorrhagic fever virus(CCHFV) Expression Epitope Nucleocapsid protein(NP) |
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