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Synthesis of peptides employing 9-fluorenylmethyl chloroformate as a coupling agent |
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| Authors: | Subramanyam J Tantry Ganga-Ramu Vasanthakumar and Vommina V Suresh Babu |
| Institution: | (1) Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India;(2) Department of Studies in Chemistry, Central College Campus, Bangalore University, Bangalore, India |
| Abstract: | The synthesis of peptides employing 9-fluorenylmethyl chloroformate(Fmoc-Cl) as a coupling agent has been described. The method is simple, efficient and rapid. All the peptides have been obtainedin good yield (70–95%). Furthermore, both the 1H NMR and the HPLC studies on Fmoc-Phg-Phe-OMe and Fmoc-D-Phg-Phe-OMe revealed that the coupling is free from racemization. |
| Keywords: | 9-fluorenylmethyl chloroformate mixed anhydride method NO-bis-trimethylsilyl-amino acids peptide acids racemization free coupling |
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