Requirements of glycerol and fatty acid for triglyceride synthesis and ketogenesis by hepatocytes from normal and triiodothyronine-treated rats |
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| Authors: | J O Olubadewo M Heimberg |
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| Affiliation: | 1. Department of Physics, Inha University, Incheon 22212, Republic of Korea;2. Department of Emerging Materials Science, DGIST, Daegu 42988, Republic of Korea;1. Department of Soil and Water Conservation and Organic Waste Management, Centro de Edafología y Biología Aplicada del Segura, CSIC, PO Box 164, 30100 Murcia, Spain;2. Department of Agrochemistry and Environment, Miguel Hernandez University, EPS-Orihuela, Ctra. Beniel Km 3.2, 03312 Orihuela, Alicante, Spain;3. Department of Agrochemistry and Biochemistry, University of Alicante, Apartado 99, E-03080 Alicante, Spain;1. Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKM’s NMIMS, Mumbai, Maharashtra, India;2. SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, Mumbai, Maharashtra, India;3. Birla Institute of Technology and Science, Pilani, Rajasthan, India;1. Ataturk University, Faculty of Medicine, Department of Otorhinolaryngology, Erzurum, Turkey;2. Ataturk University, Faculty of Medicine, Department of Radiation Oncology, Erzurum, Turkey;3. Ataturk University, Faculty of Veterinary, Department of Pathology, Erzurum, Turkey;4. Ataturk University, Faculty of Medicine, Department of Biochemistry, Erzurum, Turkey |
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| Abstract: | Hepatocytes from T3-treated rats synthesized less triglyceride and more ketone bodies from [1-14C]oleate at all concentrations from 0-2 mM, than did hepatocytes from euthyroid animals; addition of 1.0 mM glycerol increased triglyceride synthesis and reduced ketogenesis in hepatocytes from T3-treated rats to the rates observed in euthyroid hepatocytes in the absence of added glycerol. Glycerol did not alter triglyceride synthesis, but reduced ketogenesis genesis by euthyroid hepatocytes. It is probable from these and other data (J. Biol. Chem. 259, 8857-8862 (1985)) that, in the hyperthyroid rat, glycero-3-P, and not fatty acid, is rate limiting for synthesis of triglyceride, and, secondarily for reducing rates of ketogenesis in the hepatocyte. |
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