A wasp venom mastoparan-induced polyphosphoinositide breakdown in rat peritoneal mast cells |
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| Authors: | Y Okano H Takagi T Tohmatsu S Nakashima Y Kuroda K Saito Y Nozawa |
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| Affiliation: | 1. Department of Biochemistry, Gifu University School of Medicine, Tsukasamachi-40, Gifu 500, Japan;2. Department of Neurochemistry, Tokyo Metropolitan Institute for Neurosciences, 2-6 Musashidai, Fuchu, Tokyo 183, Japan;3. Department of Biophysics and Biochemistry, Faculty of Science, University of Tokyo, Bunkyo-ku, Tokyo 113, Japan |
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| Abstract: | The phospholipid metabolism of rat peritoneal mast cells stimulated with mastoparan, a secretagogue purified from wasp venom, was investigated. Mastoparan at 20 micrograms/ml caused a rapid secretion of histamine. Mastoparan induced a transient decrease of phosphatidylinositol 4,5-biphosphate on 32P labeling and generation of a water-soluble degradation product, inositol trisphosphate on [3H]inositol labeling, suggesting the activation of phospholipase C upon stimulation. |
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