The optical activity and circular dichroic spectra of diacetylenic phospholipid polymers |
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Authors: | Miquel Pons David Samuel Johnston Dennis Chapman |
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Institution: | Department of Biochemistry and Chemistry, Royal Free Hospital School of Medicine, (University of London), 8, Hunter Street, London, WC1N 1BP U.K. |
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Abstract: | Phospholipids (phosphatidylcholines) which contain a diacetylene group in a single acyl chain and within both acyl chains have been synthesized. Upon irradiation with ultraviolet light, both types of lipid crosslink via the diacetylene groups to produce coloured polymers. The colour arises form the conjugated double and triple bonds which make up the polymer backbone. These phospholipid polymers can exhibit optical activity, as shown by their circular dichroic spectra. The optical activity is thought to stem from asymmetric packing of the polydiacetylene chains, a packing of one particular screw sense being favoured by the chiral glycerol moiety of the lipid. The presence of an intrinsic membrane protein within the liposome structure affects the CD spectra of polymer produced by irradiation. |
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Keywords: | Phospholipid polymer Diacetylene polymerization Circular dichroism |
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