The effect of nisin on murein synthesis |
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| Authors: | Peter Reisinger Heinz Seidel Harald Tschesche Walter P. Hammes |
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| Affiliation: | (1) Botanisches Institut der Universität München, Menzinger Straße 67, D-8000 München 19, Federal Republic of Germany;(2) Universität Bielefeld, Postfach 8640, D-4800 Bielefeld 1, Federal Republic of Germany;(3) Present address: Institut für Lebensmitteltechnologie, Garbenstr. 25, D-7000 Stuttgart 70, Federal Republic of Germany |
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| Abstract: | Nisin inhibits murein synthesis with concomitant accumulation of undecaprenyl-pyrophospho-MurNAc(pentapeptide) (lipid intermediate I). This inhibition is caused by the formation of a complex between the antibiotic and lipid intermediate I. Undecaprenyl-pyrophospho-MurNAc(pentapeptide)-GlcNAc (lipid intermediate II) also forms a complex with nisin. However, when murein synthesis is inhibited by nisin, this latter complex is not formed since lipid intermediate II is no longer synthesized.Abbreviations GlcNAc N-acetylglucosamine - MurNAc N-acetylmuramyl - Pentapeptide Ala- -DGlu-Lys-DAla-DAla - C55 undecaprenolDedicated to Professor Otto Kandler on occasion of his 60th birthday |
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| Keywords: | Antibiotics Murein (peptidoglycan) synthesis Nisin |
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