| 光敏掩蔽基团在化学生物学中的应用 |
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| 引用本文： | 朱洁平,李峰,李宜明. 光敏掩蔽基团在化学生物学中的应用[J]. 中国细胞生物学学报, 2011, 0(12): 1386-1393 |
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| 作者姓名： | 朱洁平 李峰 李宜明 |
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| 作者单位： | 皖西卫生职业学院;清华大学化学系 |
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| 基金项目： | 国家自然科学基金(No.90713009)资助项目~~ |
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| 摘 要： | 光敏掩蔽基团技术是通过运用一种由光子控制的光敏化合物,在光子激发后,被该化合物掩蔽处于惰性状态的生物活性分子重新被激活、释放以调节生理功能的化学生物学研究方法,它对生命活动的控制具有实时、原位、精确、快速的优势。该文综述了不同光敏基团的结构与功能,包括硝基苄基类、香豆素类、喹啉类、吲哚类、硝基二苯并呋喃类等,它们通过掩蔽神经递质、钙离子、蛋白质、缩氨酸、核苷酸、遗传物质等重要的生理活性物质来高选择性地调控不同的生物学过程。
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| 关 键 词： | 光子 光敏掩蔽基团 生物活性分子 光子激发 |
The Application of Photo Caging Group in Chemical Biology |
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| Zhu Jieping,Li Feng,Li Yiming. The Application of Photo Caging Group in Chemical Biology[J]. , 2011, 0(12): 1386-1393 |
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| Authors: | Zhu Jieping Li Feng Li Yiming |
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| Affiliation: | (2*) (1 West Anhui Health Vocational College,Liuan 237005,China;2 Department of Chemistry,Tsinghua University, Beijing 100084,China) |
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| Abstract: | The technology of photo-caging group is a novel Chemical-Biology approach,which was used to regulate the mechanism of life science.The term "caging" refers to installation of a photoremovable group on a biologically active molecule and encapsulates molecule in an inactive form.Irradiation with light removes the caging group and restores biological activity.This method provides unique possibilities for controlling bio-molecular function with high spatial and temporal resolution.This paper summarizes the structure and function of these lightsensitive compounds including nitrobenzyl,coumarin,quinoline,indole,nitrodibenzofuran.They adjust diverse biological processes selectively by caging physiological functional molecule such as neurotransmitter,calcium,protein, peptide,nucleotide and germ plasm. |
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| Keywords: | photon photo caging group bio-active molecule light-activited |
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