Synthesis of a coumarin based fluorescent amino acid |
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| Authors: | Sui Guodong Kele Péter Orbulescu Jhony Huo Qun Leblanc Roger M |
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| Institution: | (1) Center for Supramolecular Science and Department of Chemistry, University of Miami, 1301 Memorial Drive, 33124 Coral Gables, U.S.A. |
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| Abstract: | Summary
l-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid (l-Adp), as a non-proteinogenic fluorescent amino acid has been synthesized by a highly stereoselective routine (>99.5%). This
fluorescent amino acid, as fluorophorequencher pair, may be used to study peptide assays. For enantiomeric excess determination,
the racemicdl-Adp (dl-2-amino-3-(6,7-dimethoxy-4-coumaryl)-propionic acid) has also been synthesized. |
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| Keywords: | coumarin fluorescence spectra fluorescent label fluorophore-quencher |
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