Activity of tubercidin-, toyocomycin-, and sangivamycin-3',5'-cyclic phosphates and related compounds with some enzymes of adenosine-3',5'-cyclic phosphate metabolism |
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| Authors: | J P Miller K H Boswell K Muneyama R L Tolman M B Scholten R K Robins L N Simon D A Shuman |
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| Affiliation: | Department of Anatomy and Cell Biology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15261 USA |
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| Abstract: | Rat liver nuclei contain at least two DNA polymerases that can be separated by extracting the nuclei with 5% Brij 58. The loosely-bound activity increases little or not at all after partial hepatectomy and is insensitive to cytosine arabinoside triphosphate (araCTP). The tightly-bound enzyme activity rises along with DNA replication and is inhibited by araCTP. |
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