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1,4-Disubstituted imidazoles are potential antibacterial agents functioning as inhibitors of enoyl acyl carrier protein reductase (FabI) |
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| Authors: | Heerding D A Chan G DeWolf W E Fosberry A P Janson C A Jaworski D D McManus E Miller W H Moore T D Payne D J Qiu X Rittenhouse S F Slater-Radosti C Smith W Takata D T Vaidya K S Yuan C C Huffman W F |
| Institution: | GlaxoSmithKline Pharmaceuticals, Antibacterials and Host Defense, 1250 S. Collegeville Road, Collegeville, PA 19426, USA. dirk_a_heerding@sbphrd.com |
| Abstract: | 1,4-Disubstituted imidazole inhibitors of Staphylococcus aureus and Escherichia coli enoyl acyl carrier protein reductase (FabI) have been identified. Crystal structure data shows the inhibitor 1 bound in the enzyme active site of E. coli FabI. |
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