Characterization and simulation of cDNA microarray spots using a novel mathematical model |
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| Authors: | Hye Young Kim Seo Eun Lee Min Jung Kim Jin Il Han Bo Kyung Kim Yong Sung Lee Young Seek Lee Jin Hyuk Kim |
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| Institution: | (1) Department of Physiology, College of Medicine,Hanyang University, Seoul, 133-791, Korea;(2) Department of Biochemistry and Molecular Biology, College of Medicine,Hanyang University, Seoul, 133-791, Korea;(3) Division of Molecular & Life Science, College of Science and Technology, Hanyang University, Ansan, 426-791, Korea |
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| Abstract: | Background The quality of cDNA microarray data is crucial for expanding its application to other research areas, such as the study of
gene regulatory networks. Despite the fact that a number of algorithms have been suggested to increase the accuracy of microarray
gene expression data, it is necessary to obtain reliable microarray images by improving wet-lab experiments. As the first
step of a cDNA microarray experiment, spotting cDNA probes is critical to determining the quality of spot images. |
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