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Characterization and simulation of cDNA microarray spots using a novel mathematical model
Authors:Hye Young Kim  Seo Eun Lee  Min Jung Kim  Jin Il Han  Bo Kyung Kim  Yong Sung Lee  Young Seek Lee  Jin Hyuk Kim
Institution:(1) Department of Physiology, College of Medicine,Hanyang University, Seoul, 133-791, Korea;(2) Department of Biochemistry and Molecular Biology, College of Medicine,Hanyang University, Seoul, 133-791, Korea;(3) Division of Molecular & Life Science, College of Science and Technology, Hanyang University, Ansan, 426-791, Korea
Abstract:

Background  

The quality of cDNA microarray data is crucial for expanding its application to other research areas, such as the study of gene regulatory networks. Despite the fact that a number of algorithms have been suggested to increase the accuracy of microarray gene expression data, it is necessary to obtain reliable microarray images by improving wet-lab experiments. As the first step of a cDNA microarray experiment, spotting cDNA probes is critical to determining the quality of spot images.
Keywords:
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