Cells of the synovium in rheumatoid arthritis. T lymphocytes |
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Authors: | Steven K Lundy Sujata Sarkar Laura A Tesmer David A Fox |
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Institution: | (1) Department of Internal Medicine, Division of Rheumatology and Rheumatic Diseases Core Center, University of Michigan Medical School, 4043 Biomedical Sciences Research Bldg, 109 Zina Pitcher Pl, Ann Arbor, MI 48109-2200, USA; |
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Abstract: | Recent findings have substantiated the importance of T lymphocytes to the pathogenesis of rheumatoid arthritis (RA). Here,
we review emerging data regarding genetic predisposition, spontaneous animal models of arthritis, and cell-cell interactions
that implicate T cells as driving synovial inflammation and joint destruction. Information regarding the proinflammatory role
of interleukin-17-producing T cells and the functional state of regulatory T cells both in animal models and in patients with
RA is also discussed. In light of the overwhelming evidence that disrupted T-cell homeostasis greatly contributes to joint
pathology in RA, the therapeutic potential of targeting activators of pro-inflammatory T cells or their products is compelling. |
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Keywords: | |
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