Genetic polymorphism in a VEGF-independent angiogenesis gene ANGPT1 and overall survival of colorectal cancer patients after surgical resection |
| |
Authors: | Dai Jingyao Wan Shaogui Zhou Feng Myers Ronald E Guo Xu Li Bingshan Fu Xiaoying Palazzo Juan P Dou Kefeng Yang Hushan Xing Jinliang |
| |
Institution: | Department of Hepatobiliary Surgery, Xijing Hospital, The Fourth Military Medical University, Xi'an, China. |
| |
Abstract: | BackgroundThe VEGF-independent angiogenic signaling plays an important role in the development of colorectal cancer (CRC). However, its implication in the clinical outcome of CRC has not been reported. This study aimed to investigate the association between genetic variations in several major VEGF-independent signaling pathway genes and the overall survival of CRC patients.MethodsSeven single nucleotide polymorphisms (SNPs) in four important VEGF-independent angiogenic genes (ANGPT1, AMOT, DLL4 and ENG) were genotyped in a Chinese population with 408 CRC patients.ResultsOne SNP, rs1954727 in ANGPT1, was significantly associated with CRC overall survival. Compared to patients with the homozygous wild-type genotype of rs1954727, those with heterozygous and homozygous variant genotypes exhibited a favorable overall survival with a hazard ratio (HR) of 0.89 (95% confidence interval CI] 0.55–1.43, P?=?0.623), and 0.32 (95% CI 0.15–0.71, P?=?0.005), respectively (P trend?=?0.008). In stratified analysis, this association remained significant in patients receiving chemotherapy (P trend?=?0.012), but not in those without chemotherapy. We further evaluated the effects of chemotherapy on CRC survival that was stratified by rs1954727 genotypes. We found that chemotherapy resulted in a significantly better overall survival in the CRC patients (HR?=?0.44, 95% CI 0.26–0.75, P?=?0.002), which was especially prominent in those patients with the heterozygous genotype of rs1954727 (HR?=?0.45, 95%CI 0.22–0.92, P?=?0.028). ConclusionOur data suggest that rs1954727 in ANGPT1 gene might be a prognostic biomarker for the overall survival of CRC patients, especially in those receiving chemotherapy, a finding that warrants validation in larger independent populations. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|