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The celiac ganglion modulates LH-induced inhibition of androstenedione release in late pregnant rat ovaries
Authors:Marilina Casais  Silvia M Delgado  Zulema Sosa  Carlos M Telleria  Ana M Rastrilla
Institution:1. Laboratorio de Biología de la Reproducción (LABIR), Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, 5700, San Luis, Argentina
2. Division of Basic Biomedical Sciences, Sanford School of Medicine of the University of South Dakota, 57069, Vermillion, South Dakota, USA
Abstract:

Background  

Although the control of ovarian production of steroid hormones is mainly of endocrine nature, there is increasing evidence that the nervous system also influences ovarian steroidogenic output. The purpose of this work was to study whether the celiac ganglion modulates, via the superior ovarian nerve, the anti-steroidogenic effect of LH in the rat ovary. Using mid- and late-pregnant rats, we set up to study: 1) the influence of the noradrenergic stimulation of the celiac ganglion on the ovarian production of the luteotropic hormone androstenedione; 2) the modulatory effect of noradrenaline at the celiac ganglion on the anti-steroidogenic effect of LH in the ovary; and 3) the involvement of catecholaminergic neurotransmitters released in the ovary upon the combination of noradrenergic stimulation of the celiac ganglion and LH treatment of the ovary.
Keywords:
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