A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells. |
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| Authors: | M Ernoult-Lange M Kress and D Hamer |
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| Institution: | Laboratory of Biochemistry, National Cancer Institute, Bethesda, Maryland 20892. |
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| Abstract: | We describe the cloning and characterization of the mouse MOK-2 gene, a new member of the Krüppel family of zinc finger proteins. Sequencing of both cDNA and genomic clones showed that the predicted MOK-2 protein consists of seven zinc finger domains with only five additional amino acids. The finger domains of MOK-2 are highly homologous to one another but not to those of other zinc finger proteins. MOK-2 is preferentially expressed in transformed cell lines, brain tissue, and testis tissue. Its possible role in cellular transformation is discussed. |
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