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Synthesis and cytotoxic activity of novel quinazolino-beta-carboline-5-one derivatives |
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| Authors: | Baruah Bipul Dasu Kavitha Vaitilingam Balasubramanian Mamnoor Premkumar Venkata Prasanthi Penubaka Rajagopal Sriram Yeleswarapu Koteswar Rao |
| Institution: | Discovery Chemistry, Discovery Research, Dr. Reddy's Laboratories Limited, Bollaram Road, Miyapur, Hyderabad 500050, India. |
| Abstract: | A novel series of quinazolino-beta-carbolinone derivatives was synthesized and evaluated for their in vitro and in vivo anticancer activity. Many compounds have shown good in vitro activity in the range 1-8 microM concentration. Three of the compounds were further tested in nude mice bearing HT-29 colon cancer xenografts. |
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