Effects of D-amino acids on lipoperoxidation in rat liver and kidney mitochondria |
| |
| Authors: | C Cortés-Rojo M Clemente-Guerrero A Saavedra-Molina |
| |
| Institution: | (1) Instituto de Investigaciones Químico-Biológicas, Universidad Michoacana de San Nicolás de Hidalgo, Morelia, México |
| |
| Abstract: | Summary. The effects of the amino acids D-ser, D-asp, and D-ala on lipoperoxidation under conditions of hypertension, alcoholism, and
ammonemia in rat liver and kidney mitochondria were studied. Under normal conditions, D-alanine increased in 54% free radicals
production in liver mitochondria (p < 0.05). The D-amino acids had no effect on kidney mitochondria. D-ser and D-ala increased lipoperoxidation in spontaneously
hypertensive rats (SHR) as compared with their normotensive genetic control Wistar-Kyoto (WKY) rats (p < 0.05). During hypertension and in oxidative stress in the presence of calcium, only D-ala produced 46% and 29% free radicals
in liver and kidney mitochondria (p < 0.05), respectively. During chronic alcoholism, D-ser increased lipoperoxidation in 80% in kidney mitochondria (p < 0.05), as compared to control. During ammonemia, D-ser produced 41% free radicals. |
| |
| Keywords: | : Lipoperoxidation – D-amino acids – Hypertension – Oxidative stress – Chronic alcoholism – Liver mitochondria – Kidney mitochondria |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
