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Global approaches to understanding ubiquitination
Authors:Peter?Kaiser  author-information"  >  author-information__contact u-icon-before"  >  mailto:pkaiser@uci.edu"   title="  pkaiser@uci.edu"   itemprop="  email"   data-track="  click"   data-track-action="  Email author"   data-track-label="  "  >Email author,Lan?Huang
Affiliation:(1) Department of Biological Chemistry, School of Medicine, University of California, Irvine, CA 92697-1700, USA;(2) Department of Physiology and Biophysics, University of California, Irvine, CA 92697-1700, USA;(3) Department of Developmental and Cell Biology, University of California, Irvine, CA 92697-1700, USA
Abstract:Ubiquitination - the linkage of one or more molecules of the protein ubiquitin to another protein - regulates a wide range of biological processes in all eukaryotes. We review the proteome-wide strategies that are being used to study aspects of ubiquitin biology, including substrates, components of the proteasome and ubiquitin ligases, and deubiquitination.
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