Comparison of the effects of volatile anesthetics in varying concentrations on brain energy metabolism with brain ischemia in rats |
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| Authors: | Mark Zapp W Andrew Kofke MD Donald W Davis |
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| Institution: | (1) Department of Anesthesia, College of Medicine, University of Florida, Gainesville, Florida;(2) Department of Anesthesiology/Critical Care Medicine, University of Pittsburgh, 1385 Scaife Hall, 15261 Pittsburgh, PA;(3) Department of Neurologic Surgery, Neurologic Anesthesia and Supportive Care Program, School of Medicine, University of Pittsburgh, 1385 Scaife Hall, 15261 Pittsburgh, PA;(4) Department of Anesthesia, Emory University School of Medicine, Atlanta, Georgia |
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| Abstract: | The effects of varying concentrations and types of volatile anesthetics on neurochemical sequelae of brain ischemia were evaluated in the rat. Rats were assigned to treatment defined by a 3×3 design (anesthetic type and dose) with 5 rats/cell. Each group received halothane, enflurane, or isoflurane 0.5, 1.0, or 2.0 MAC (minimal alevolar concentration). This was followed by preischemic plasma glucose sampling, 5 min hypotension (30 mmHg) and 5 min decapitation cerebral ischemia. Preischemia plasma glucose increased with increasing anesthetic concentration and was highest in the isoflurane groups, varying from a low (±SD) of 7.19±1.79  mol/ml in the 0.5 MAC halothane group to a high of 12.68±3.65 mol/ml in the 2.0 MAC isoflurane group. End-ischemic brain lactate correlated with preischemic plasma glucose (r=0.5,  =0.5). We conclude that increasing concentration of volatile anesthesia with iv phenylephrine blood pressure support produces higher levels of plasma glucose and brain lactate with cerebral ischemia. |
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| Keywords: | Anoxia anesthetics depth metabolism volatile glucose hyperglycemia lactate metabolism |
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