Assessment of cell engineering strategies for improved therapeutic protein production in CHO cells |
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| Authors: | Mohan Chaya Kim Yeon-Gu Koo Jane Lee Gyun Min |
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| Institution: | Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejon, Korea. |
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| Abstract: | Recombinant glycoprotein therapeutics have proven to be invaluable pharmaceuticals for the treatment of various diseases. Chinese hamster ovary (CHO) cells are widely used in industry for the production of these proteins. Several strategies for engineering CHO cells for improved protein production have been tried with considerable results. The focus has mainly been to increase the specific productivity and to extend the culture longevity by preventing programmed cell death. These CHO cell engineering strategies, particularly those developed in Korea, are reviewed here. |
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| Keywords: | Apoptosis Chinese hamster ovary cells Molecular chaperones Specific productivity |
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