The RNase P ofDictostyelium discoideum |
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Authors: | Denis Drainas |
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Affiliation: | (1) Department of Biochemistry, School of Medicine, University of Patras, 26500 Rio-Patras, Greece |
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Abstract: | Ribonuclease P (RNase P) is a key enzyme involved in tRNA biosynthesis. It catalyses the endonucleolytic cleavage of nearly all tRNA precursors to produce 5-end matured tRNA. RNase P activity has been found in all organisms examined, from bacteria to mammals. Eubacterial RNase P RNA is the only known RNA enzyme which functionsin trans in nature. Similar behaviour has not been demonstrated in RNase P enzymes examined from archaebacteria or eukaryotes. Characterisation of RNase P enzymes from more diverse eukaryotic species, including the slime moldDictyostelium discoideum, is useful for comparative analysis of the structure and function of eukaryotic RNase P.Abbreviations RNase P ribonuclease P - MN micrococcal nuclease |
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Keywords: | Dictyostelium discoideum ribonuclease P ribozyme |
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