The scanning model for translation: an update |
| |
Authors: | M Kozak |
| |
Affiliation: | Department of Biological Sciences, University of Pittsburgh, Pennsylvania 15260. |
| |
Abstract: | The small (40S) subunit of eukaryotic ribosomes is believed to bind initially at the capped 5'-end of messenger RNA and then migrate, stopping at the first AUG codon in a favorable context for initiating translation. The first-AUG rule is not absolute, but there are rules for breaking the rule. Some anomalous observations that seemed to contradict the scanning mechanism now appear to be artifacts. A few genuine anomalies remain unexplained. |
| |
Keywords: | |
|
|